Purchase liquid vitamin E. Dab the liquid onto the dark spots on your face. If you don’t have liquid vitamin E, buy vitamin E capsules. Open the capsules and mix with little water until a thin liquid is formed. This remedy provides the skin with plenty antioxidants to help even your skin tone.
To explore the underlying mechanism and treatment of myocardial injury caused by hypothyroidism, we evaluated oxidative stress in serum and myocardial tissue of hypothyroid rats. The effect of levothyroxine (LT4) replacement therapy and vitamin E (VitE) supplementation on oxidative stress-induced injury and apoptosis of myocardial tissue is examined.
Male Sprague-Dawley rats were divided into five groups: normal control group, propylthiouracil group (PTU group), LT4 treatment group (PTU + LT4 group), vitamin E treatment group (PTU + VitE group), and combined treatment group (PTU + LT4 + VitE group). Superoxide dismutase (SOD) activity and malondialdehyde (MDA) expression in serum and myocardium were determined. Myocardial apoptosis index (AI) in each group was determined by TUNEL assay.
SOD levels in serum were significantly increased in PTU + VitE and PTU + LT4 + Vit E groups, as compared to that in PTU and PTU + LT4 groups (P < 0.05). MDA levels in serum and myocardial tissue were significantly lower in PTU + LT4, PTU + VitE, and PTU + LT4 + VitE groups, as compared to that in the PTU group (P < 0.05). Myocardial apoptosis was significantly increased in PTU and PTU + VitE groups as compared to that in the normal control group (P < 0.05), while it was significantly lower in PTU + LT4 and PTU + LT4 + VitE groups, as compared to that in the PTU group (P < 0.05).
In this study, levothyroxine replacement therapy and vitamin E supplementation appeared to ameliorate myocardial apoptosis in hypothyroid rats, the mechanism of which appears to be related to improved thyroid function and reduced oxidative stress.
Severe Acute Liver Failure (ALF) is a life-threatening clinical syndrome characterized by hepatocyte necrosis, loss of hepatic architecture, and impairment of liver functions. One of the main causes of ALF is hepatotoxicity from chemical agents, which damage hepatocytes and result in increase of reactive oxygen species. The vitamin E isoform is the one with the strongest biological antioxidant activity.
To evaluate the antioxidant effect of vitamin E in this ALF model.
We used 56 rats (mean weight of 300 g) divided into eight groups, four groups assessed at 24 hours and 4 assessed at 48 hours after induction: control group (CO); Vitamin E (Vit. E); Thioacetamide (TAA) and Thioacetamide + Vitamina E (TAA+Vit.E). Rats were submitted to injections of thioacetamide (400 mg/kg i.p.) at baseline and 8 hours later. Vitamin E (100 mg/kg ip) was administered 30 minutes after the second dose of thioacetamide. The 48-hour group rats received two additional doses of vitamin E (24h and 36h). At 24h or 48 hours after the administration of the first dose of TAA, rats were weighed and anesthetized and their blood sampled for evaluation of liver integrity through enzymes aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Liver tissue was sampled for assessment of lipid peroxidation (LPO) by the technique TBARS, antioxidant enzymes SOD, CAT, GPx and GST activity, levels of the NO 2 /NO 3 and histology by H&E in two times. The results were expressed as mean ± standard deviation and statistically analyzed by ANOVA followed by Student-Newman-Keuls, with P <0.05 considered as significant.
These results suggest that vitamin E was able to protect the liver from lesions caused by thioacetamide.
The lungs cry for vitamin E. Researchers at Harvard University have found that those persons who have an ample amount of vitamin E in their diets are less likely to have attacks of asthma. It has been shown that vitamin E relaxes the smooth muscle surrounding the small tubes in the lungs, preventing them from collapsing. Vitamin E can be found in such foods as wheat germ, almonds, sunflower seeds, whole grain cereals, spinach and kale. If your diet is low in these foods, a supplement of vitamin E (200 IU to 400 IU) may help to prevent asthma.
PUTRAJAYA: As global palm oil consumption increases over the decades to 50 million tonnes a year, so has the intensity of smear campaigns against the industry. “The US$40 billion (RM177 billion) global palm oil trade makes up almost 60 per cent of the world’s vegetable oil market. But the bigger the palm oil industry, the easier it is for smear campaigns to target our planters,” Plantation Industries and Commodities Minister Datuk Seri Mah Siew Keong told NST Business in an interview, here.
Biofortified maize is not only a good vehicle for provitamin A carotenoids for vitamin A deficient populations in developing countries but also a source of vitamin E, tocochromanols and phenolic compounds, which have antioxidant properties. Using high-performance liquid chromatography and a total antioxidant performance assay, the present study analyzed the antioxidant variation and antioxidant activity of 36 provitamin A improved maize hybrids and one common yellow maize hybrid. The ranges of major carotenoids in provitamin A carotenoids biofortified maize were zeaxanthin [1.2-13.2 µg g-1 dry weight (DW)], β-cryptoxanthin (1.3-8.8 µg g-1 DW) and β-carotene (1.3-8.0 µg g-1 DW). The ranges of vitamin E compounds identified in provitamin A carotenoids biofortified maize were α-tocopherol (3.4-34.3 µg g-1 DW), γ-tocopherol (5.9-54.4 µg g-1 DW), α-tocotrienol (2.6-19.5 µg g-1 DW) and γ-tocotrienol (45.4 µg g-1 DW). The ranges of phenolic compounds were γ-oryzanol (0.0-0.8 mg g-1 DW), ferulic acid (0.4-3.6 mg g-1 DW) and p-coumaric acid (0.1-0.45 mg g-1 DW). There was significant correlation between α-tocopherol and cis isomers of β-carotene (P < 0.01). Tocotrienols were correlated with α-tocopherol and γ-oryzanol (P < 0.01). Conclusion, genotype was significant in determining the variation in β-cryptoxanthin, β-carotene, α-tocopherol and γ-tocopherol contents (P < 0.01). A genotype × environment interaction was observed for γ-tocopherol content (P < 0.01).
In the almost 100 years since its discovery, vitamin E has been recognized as an antioxidant. However, recent findings suggest that the compound and its metabolites have roles that go beyond metabolism, gene regulation, immunomodulation, and neuroprotection. Free Radical Biology and Medicine has published a review of emerging aspects and future directions of vitamin E research in its November 2016 issue. This information, they believe, can help guide nutritional recommendations and trials on age-related and chronic disease prevention.
“The research showed that people with metabolic syndrome need about 30-50 percent more vitamin E than those who are generally healthy,” reported lead author Maret Traber of the Linus Pauling Institute. “We’ve discovered that vitamin E levels often look normal in the blood, because this micronutrient is attracted to high cholesterol and fat. So vitamin E can stay at higher levels in the circulatory system and give the illusion of adequate levels, even as tissues are deficient. This basically means that conventional vitamin E blood tests as they are now being done are useless.”
MEDIA BUZZ: Malaysian certified sustainable palm oil is getting its fair share of mainstream media attention for its nutrition and weight-management benefits. Malaysian palm oil was highlighted in top women’s magazine Marie Claire in a weight-loss article that reached more than a million women. Olive oil wasn’t even mentioned!
This study aimed to investigate the feasibility of producing semisolid formulations based on nanocapsule suspensions containing the association of the coenzyme Q10 and vitamin E acetate by adding gellan gum (2%) to the suspensions. Furthermore, we studied their application as an alternative for the treatment of inflammation induced by ultraviolet B (UVB) radiation. For this, an animal model of injury induced by UVB-radiation was employed. All semisolids presented pH close to 5.5, drug content above 95% and mean diameter on the nanometric range, after redispersion in water. Besides, the semisolids presented non-Newtonian flow with pseudoplastic behavior and suitable spreadability factor values. The results also showed that the semisolid containing coenzyme Q10-loaded nanocapsules with higher vitamin E acetate concentration reduced in 73±8% the UVB radiation-induced ear edema. Moreover, all formulations tested were able to reduce inflammation parameters evaluated through MPO activity and histological procedure on injured tissue and the semisolids containing the nanoencapsulated coenzyme Q10 reduced oxidative parameters assessment through the non-protein thiols levels and lipid peroxidation. This way, the semisolids based on nanocapsules may be considered a promising approach for the treatment and prevention of skin inflammation diseases.