A study has found that people with Alzheimer’s disease showed significantly lower plasmatic concentration of total tocopherols, total tocotrienols and total vitamin E (full-spectrum vitamin E consisting of all eight isoforms) compared to cognitively healthy subjects. The researchers also measured the leukocyte telomere length (LTL), which has been known to be associated with cognitive decline as well as decline in LTL with aging. The study showed the LTL is shorter in Alzheimer subjects and also that excessive nitrosylation of γ-tocopherol influences the risk of developing Alzheimer’s only in those individuals with preserved telomere length (i.e., biologically younger).
