Drug-resistant human breast cancer cells express high levels of Stat-3 signalling mediators essential for enrichment of cancer stem cells. Alone or in combination with simvastatin , low doses of gamma-tocotrienol eliminates human breast cancer stem cells via inhibition of the mevalonate pathway and activation of the novo ceramide synthesis pathways.
Tocotrienol exerts a synergistic effect with alpha-tocopherol on rat models of steatohepatitis (fatty liver). Results have shown that lipid peroxide levels in the liver are lower and signs of increased liver damage are controlled after combined intake of tocotrienol and alpha-tocopherol. High levels of inflammatory cytokines mRNA suppression were observed and particularly, the gamma-isoform of tocotrienol significantly inhibited mRNA expression of TGF-beta1.
Studies published in international peer-reviewed journals have highlighted Vitamin E’s neuroprotective benefits, an activity largely attributed to Vitamin E’s antioxidant properties. Oxidative stress plays a major role in the development and progression of AD. Results from the Rotterdam Study, one of the largest study to date on the effects of dietary antioxidant intake on dementia risk in over 5,000 subjects have shown that high intake of vitamin E- rich food sources can modestly reduce the long-term risk of dementia and AD.
The Dr Oz Show, a widely followed television series focusing on personal health and integrative medicine hosted by multi-awarded heart surgeon Dr Oz, recently presented its views on the health benefits of red palm oil from the fruit of the oil palm tree (Elais guineensis).
In the show’s January 3, 2013 episode, Dr Oz and his guest, Bryce Wylde, recommend red palm oil particularly for its tocotrienol, a novel form of vitamin E found in the oil palm fruit. On his show Dr Oz called the red palm oil as the “most miraculous find of 2013”. According to Dr. Oz, tocotrienols possess stellar antioxidation properties and unique health benefits that support heart and brain health.
Ooi Tee Ching
A Life Saver: As more medical researchers all over the world discover the unique ability of palm oil vitamin E in seeking and killing cancer cells, Malaysia steps up funding for such studies in the hope of saving more lives.
Over the last 30 years, scientific studies have shown that palm oil vitamin E, particularly the tocotrienols, is a far more potent antioxidant than tocopherols.
Numerous studies over the past two decades have clearly proven that the tocotrienol form of vitamin E is a top choice for cardiovascular protection and heart health. A recent review of tocotrienol science points out that they are also being researched for benefits to bone health, blood sugar metabolism, brain health, and cancer. Tocotrienols offer a safe and effective way to help achieve or maintain healthy cholesterol, while simultaneously protecting your arteries. It is worthwhile understanding more about them and how they can improve your health.
WHO report states that cardiovascular disease (CVD) remains a leading cause of death and disability worldwide. Though preventable, an expected 23.6 million people will die mainly from CVD by 2030. To help support cardiovascular health, the majority of nutraceuticals are directed towards promoting heart and blood vessel health through reduction in the level of body lipids such as cholesterol and triglyceride.
Encouraging results from several studies show vitamin E tocotrienol’s anti-tumour properties in various cancer types. Breast Cancer – A study showed that gamma tocotrienol, at levels of dietary supplement intake, reduced the spreading of breast cancer cells by 58%.
After reviewing the available science and biochemistry on gamma tocotrienol Specialized form of vitamin E. Powerful antioxidant showing positive benefits for cholesterol, cardiovascular, neurological health and cancer risk reduction. and cancer, researchers from the University of Louisiana at Monroe proclaimed, “The synergistic anti-proliferative and apoptotic effects demonstrated by combined low dose treatment of gamma tocotrienol Specialized form of vitamin E. Powerful antioxidant showing positive benefits for cholesterol, cardiovascular, neurological health and cancer risk reduction. with other chemotherapeutic agents may provide significant health benefits in the prevention and/or treatment of breast cancer in women, while at the same time avoiding tumor resistance and toxic side effects associated with high dose monotherapy.”
Over the course of time, healthy skin often succumbs to the cumulative effects of external factors such as ultraviolet radiation and environmental pollutants. Free radical damage caused by normal cell functioning ultimately takes its toll as well, destroying the skin’s integrity from the inside. Fortunately, there are a number of safe and natural substances that have been scientifically proven to effectively help counteract, and in some cases, even help reverse the physical signs of skin aging such as wrinkles and hyperpigmentation. One of these is topically applied vitamin E.