DavosLife E3 Tocotrienols

Tocotrienols are perfect bioactive ingredients to protect the skin from PM 2.5-induced oxidative stress and inflammation. They have added benefits to potentially restore skin barrier function that has been disrupted by PM 2.5 exposure.

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Hair loss: The supplement which can increase hair growth ‘significantly’ – study findings

In the study 21 volunteers were randomly assigned to orally receive 100 mg of mixed tocotrienols daily while 17 volunteers were assigned to receive placebo capsules orally. The volunteers were monitored for the number of hairs in a predetermined scalp area. The study found the number of hairs of the volunteers in the tocotrienol supplementation group “increased significantly” as compared to the placebo group.

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Tocotrienol rules boost: Malaysia’s pending health claims will be beneficial in driving consumer awareness

Malaysia’s pending approval on palm tocotrienol’s antioxidant claims could help consumers gain a better understanding of the locally grown crop’s health benefits. There are 2 proposed claims: 1) TRF is an antioxidant and may help to reduce oxidative stress and 2) TRF may help to improve cognitive function. To make these claims, a product would need to contain 10mg/100g of solid TRF and 10mg/100ml of liquid TRF.

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The underrated antioxidant to hydrate weak, brittle nails

When it comes to nails, one has to be careful with the type of nail polish they put. A high-quality liquid is important and protecting the nails from becoming soft is certainly vital for its growth.

es, as much as your skin needs hydration from time to time, even your nails need to be moisturised to keep them healthy and shiny. The one ingredient that is an antioxidant that protects your cuticles is vitamin E or moisture-rich tocopherol, which is a fat-soluble vitamin. It helps to even out the nail plate (the hard part of the nail).

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Water-soluble vitamin E compounds directly inhibit SARS-CoV-2 replication and synergize with remdesivir

Researchers in the United States have shown that water-soluble derivatives of vitamin E (α-tocopherol) exhibit potent antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

Kevin Harrod from the University of Alabama at Birmingham and colleagues found that the compounds synergized with the antiviral drug remdesivir to inhibit SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) – an enzyme that is crucial for transcription and replication of the viral genome.

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Making sense of antisense gene silencing

Antisense oligonucleotide (ASO) therapies use small strands of DNA or RNA that are antisense, or complementary, to the associated gene to interfere with its expression. ASO therapies are already available for some diseases, particularly neurological disorders, but their use is at a very early stage. It is known that modifying ASOs chemically can improve the efficacy of the therapy. The team at TMDU had previously achieved gene silencing by attaching alpha-tocopherol (Toc) to ASOs. They then created Toc-HDOs by attaching Toc to DNA/RNA heteroduplex oligonucleotides, which are double-stranded molecules consisting of one strand of DNA and one strand of RNA. Toc-HDOs are more potent, stable, and efficiently taken up by target tissues than ASOs, and so have great therapeutic potential.

 

 

 

 

 

 

 

 

 

 

 

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