Osteoprotective Effects in Postmenopausal Osteoporosis Rat Model: Oral Tocotrienol vs. Intraosseous Injection of Tocotrienol-Poly Lactic-Co-Glycolic Acid Combination
Nurul 'Izzah Ibrahim, Hasnul 'Iffah Mohd Noor, Ahmad Naqib Shuid, Sharlina Mohamad, Mohd Maaruf Abdul Malik, Putri Ayu Jayusman, Ahmad Nazrun Shuid, Isa Naina Mohamed
Front Pharmacol . 2021 Nov 18;12:706747. doi: 10.3389/fphar.2021.706747. eCollection 2021.
Abstract Osteoporosis, the most common bone disease, is associated with compromised bone strength and increased risk of fracture. Previous studies have shown that oxidative stress contributes to the progression of osteoporosis. Specifically, for postmenopausal osteoporosis, the reduction in estrogen levels leads to increased oxidative stress in bone remodeling. Tocotrienol, a member of vitamin E that Read more…